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New Breakthrough in Skin Rejuvenation: Polynucleotide (PN) Injections Now Available at Our Clinic

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We are excited to introduce the latest advancement in regenerative aesthetics — Polynucleotide (PN) injection therapy — a powerful, science-backed skin rejuvenation treatment now offered at Perth Cosmetic Clinic. This cutting-edge innovation is redefining the way we approach age-related skin concerns by working at a cellular level to restore radiance, firmness, and skin health from within.

What Are Polynucleotides?

Polynucleotides (PNs) are ultra-purified DNA fragments originally derived from salmon or trout sperm (but processed to be biologically safe and inert). Unlike traditional dermal fillers that physically "fill in" wrinkles or collagen stimulators that prompt new collagen production via inflammatory pathways, PN injections act as bio-regenerators.

These naturally occurring molecules are injected into the dermis where they stimulate fibroblasts, support tissue regeneration, and enhance skin hydration, elasticity, and texture through a non-inflammatory pathway.

How Do PN Injections Work?

PNs work by targeting cellular repair and regeneration:

  • Activating fibroblasts to produce new collagen and elastin

  • Scavenging free radicals, reducing oxidative damage

  • Stimulating angiogenesis, increasing microcirculation to support oxygenation and nutrient supply to the skin

  • Repairing the extracellular matrix, improving skin density and elasticity

This biomodulatory effect results in a gradual and natural rejuvenation process, particularly effective in areas like:

  • Under the eyes (for dark circles and crepey skin)

  • Neck and décolletage

  • Fine lines on the face

  • Hands and atrophic scars

Advantages Over Traditional Fillers and Collagen Stimulators

FeaturePN InjectionsConventional Fillers (e.g., HA)Collagen Stimulators (e.g., PLLA, CaHA)

MechanismCellular regenerationVolume replacementCollagen production via inflammation

DowntimeMinimal to nonePossible swelling/bruisingPossible nodules/inflammation

SafetyVery high (biocompatible)Generally safeRisk of granuloma/nodule formation

OnsetGradual, natural-lookingImmediateDelayed (weeks to months)

Longevity6–12 months6–12 months1–2 years

PN therapy is especially suitable for patients seeking natural skin improvement without the risk of looking "overfilled" or experiencing harsh inflammatory responses. It offers restorative skin quality enhancement, rather than simply masking volume loss.

Minimal Downtime – Back to Life in Hours

One of the most appealing aspects of PN injection therapy is that downtime is virtually non-existent. Some patients may experience minor redness or pin-prick swelling immediately after the procedure, but this typically resolves within a few hours. There’s no bruising, no peeling, and no need for social downtime — allowing patients to return to work or daily activities the same day.

When Will I See Results?

Results develop gradually over 2 to 4 weeks, as the skin regenerates and repairs itself. Optimal results are usually visible after a series of 2 to 3 treatments spaced 3 to 4 weeks apart, with cumulative improvements in hydration, firmness, texture, and radiance.

Maintenance sessions every 6–12 months can help preserve these rejuvenating effects.

Why Choose Our Clinic?

At Perth Cosmetic Clinic, we stay ahead of the curve by integrating only the most evidence-based, safe, and effective skin solutions into our practice. Dr. Haipeng Wang, with dual doctorates in medicine and engineering, and formal training in aesthetic medicine from Queen Mary University of London and Harvard Medical School, ensures expert precision and personalized care in every procedure.

Our clinic is proud to offer this advanced PN regenerative therapy, tailored for patients who want to revive their skin quality with a natural and subtle approach.

Book Your Consultation Today

If you're looking for a non-invasive way to rejuvenate your skin and support long-term skin health without downtime, Polynucleotide injections may be the ideal solution. Contact us today to schedule a consultation and discover how PN therapy can help you look refreshed, radiant, and youthful — naturally.

📍 Perth Cosmetic Clinic – 321 Abernethy Road, Cloverdale WA 6105
📞 (08) 9277 3999
🌐 www.perthcosmetics.com.au

© Perth Cosmetic Clinic 2023

Tel:(08) 9277 3999

 321 Abernethy Road, Cloverdale, WA. 6105

Call us to Book a Consult today!

In Australia, health advertising is closely regulated by AHPRA. This means we do not advertise brand names of cosmetic injectables, or make promises about results. The reason is simple: treatments affect people differently, and no outcome can ever be guaranteed. Instead, we provide clear, factual information about how procedures work, the possible risks, and the limits of what they can achieve. Any decision about treatment should be made after a personal consultation with a qualified doctor, where your individual needs, medical history, and options can be discussed safely and honestly.

Understanding Botulinum Toxin – An Educational Overview

Important note: This information is provided for general educational purposes only. It is not advertising, does not recommend treatment, and should not replace a personal consultation with a qualified health practitioner.

What Is Botulinum Toxin?

Botulinum toxin is a prescription-only medicine derived from a purified protein produced by the bacterium Clostridium botulinum. In medical practice, it is used in very small, carefully controlled doses. The medicine works by temporarily blocking nerve signals to targeted muscles, which reduces their ability to contract.

This effect has a range of medical and cosmetic applications. In cosmetic practice, botulinum toxin is sometimes used to reduce the activity of facial muscles that contribute to certain lines that appear with movement, such as when frowning or squinting.

Duration of Effect

The changes produced by botulinum toxin are temporary. Muscle activity generally returns over several months, usually within 3 to 4 months, at which point a repeat treatment may be considered if clinically appropriate.

Evidence and Research

Botulinum toxin has been studied in both medical and cosmetic contexts. Published research suggests that reducing repeated muscle activity can reduce the appearance of lines that are related to movement. The degree of effect, however, varies between individuals.

It is important to emphasise that while some studies have shown measurable changes, outcomes are not guaranteed. A person’s response depends on factors such as muscle activity, skin condition, age, and other health variables.

Risks and Limitations

Like all medical procedures, the use of botulinum toxin carries potential risks. Reported side effects include:

  • Localised pain or bruising at the injection site

  • Headache

  • Temporary weakness of nearby muscles (for example, drooping of the eyelid or brow)

  • Rare allergic reactions

These effects are generally short-lived but can vary in duration. The safety and suitability of treatment can only be determined after a face-to-face medical consultation and clinical assessment.

Regulatory Position

In Australia, the use of botulinum toxin for cosmetic purposes is strictly regulated. It is a prescription-only medicine and may only be administered by a registered health practitioner with appropriate qualifications.

This article does not endorse any specific product, brand, or practitioner. It is intended only to provide general information about how this class of medicines works and the considerations involved in their use.

Conclusion

Botulinum toxin is one of several prescription medicines that may be considered in cosmetic practice. It acts by temporarily reducing targeted muscle activity, but the effects are not permanent and vary between individuals. All medical procedures carry risks, and any decision to proceed requires a personal consultation with a registered health practitioner who can provide individualised medical advice.

Educational Guide: Fillers– General Information

Disclaimer: This article provides general educational information only. It is not an advertisement or recommendation. Dermal fillers are prescription-only medicines and medical procedures that carry risks. Suitability and safety can only be determined through a consultation with a qualified health practitioner.

Why the Face Ages – A Scientific Overview

Facial changes over time are influenced by several natural processes, including:

  • Volume changes in fat pads: Redistribution and thinning of fat that normally provides support.

  • Bone remodelling: Gradual changes in facial bone structure, contributing to altered contours.

  • Skin changes: Thinning of the skin and reduction in collagen and elastin, leading to decreased elasticity.

These processes may contribute to the development of folds, hollows, or contour changes.

What Are Dermal Fillers?

Dermal fillers are substances that can be injected beneath the skin to provide temporary support or structure. Different types of fillers work in different ways:

  1. Hyaluronic Acid (HA) Fillers

    • Composed of a naturally occurring sugar molecule found in the body.

    • Effects are temporary and reversible with an enzyme (hyaluronidase).

  2. Calcium Hydroxylapatite (CaHA)

    • Contains microspheres in a gel carrier.

    • Provides structure and can stimulate collagen over time.

  3. Poly-L-lactic Acid (PLLA)

    • Stimulates collagen production gradually.

    • Effects develop over several months.

  4. Polymethylmethacrylate (PMMA)

    • A semi-permanent filler type.

    • Less commonly used due to difficulty of removal and higher risk of complications.

Areas Where Dermal Fillers May Be Used

Fillers may be considered for areas such as lips, cheeks, jawline, or folds around the mouth. The choice of filler and the duration of effect vary depending on the product used, the treatment area, and individual patient factors.

Most fillers gradually break down in the body over months to years. Hyaluronic acid fillers are naturally metabolised, while other types (such as CaHA or PLLA) degrade through different biological processes.

Risks and Possible Complications

As with all medical procedures, dermal filler treatment carries risks. Possible side effects include:

  • Bruising or swelling at the injection site

  • Lumps, nodules, or asymmetry

  • Discolouration (including the “Tyndall effect” in superficial injections)

  • Infection or inflammation

  • Vascular occlusion (a blocked blood vessel), which is rare but can lead to tissue injury or, in very rare cases, blindness

These risks may occur regardless of the type of filler or practitioner experience. The likelihood can vary between individuals.

Safety Considerations

  • Dermal filler procedures should only be performed by registered health practitioners with appropriate training.

  • Only a qualified prescriber can provide hyaluronidase, which may be required in emergencies to dissolve filler.

  • The decision to proceed with treatment should only be made after an in-person medical consultation that includes a full medical history, discussion of risks and alternatives, and informed consent.

Summary

Dermal fillers are one category of prescription-only medicines used in cosmetic medicine. They act by temporarily adding structure beneath the skin. While they may provide certain effects, outcomes vary, are temporary, and cannot be guaranteed.

Importantly, fillers are medical procedures with real risks, including rare but serious complications. Anyone considering dermal filler treatment should first have a consultation with a registered medical practitioner who can assess suitability, explain risks and limitations, and provide advice tailored to the individual.

Educational Guide: Collagen Stimulation – Microneedling, LED, Radiofrequency, and Injectable Options

Disclaimer: This resource provides general educational information. It does not advertise or recommend specific treatments or products. Collagen-stimulating procedures are medical in nature, require appropriate qualifications, and carry risks. Suitability for any procedure can only be determined after a consultation with a registered health practitioner.

Collagen and Skin Structure

Collagen is a naturally occurring protein that provides structure and resilience to the skin. Over time, collagen production reduces as part of the normal ageing process. This can contribute to changes in skin elasticity, thickness, and firmness.

A range of medical procedures aim to stimulate the body’s own collagen production. These approaches vary in method, degree of effect, and suitability for different individuals.

Microneedling (Collagen Induction Therapy)

Microneedling involves the use of sterile, fine needles to create controlled micro-injuries in the skin. This triggers a wound-healing response that can stimulate collagen and elastin production.

  • Mechanism: Activation of fibroblasts and release of growth factors.

  • Areas sometimes considered: fine lines, certain acne scars, general texture.

  • Evidence: Clinical studies have shown changes in collagen content following repeated treatments.

  • Risks: Bruising, infection, scarring, and pigmentary change are possible.

LED (Light-Emitting Diode) Therapy

LED therapy uses low-level light energy at specific wavelengths. Different wavelengths interact with the skin in different ways.

  • Red/near-infrared light: has been studied for wound healing and dermal effects.

  • Blue light: has been studied in relation to acne-causing bacteria.

  • Risks: Mild redness, irritation, or temporary sensitivity.

Radiofrequency (RF)

Radiofrequency devices deliver controlled heat to the dermis. The heating effect can trigger tissue contraction and stimulate new collagen formation.

  • Evidence: Published studies report changes in skin laxity after repeated sessions.

  • Risks: Burns, altered sensation, scarring, or variable outcomes.

  • Note: Suitability depends on device type, treatment parameters, and individual factors.

Injectable Collagen Stimulators

Some prescription-only injectable substances can stimulate collagen production over time. These are different from hyaluronic acid fillers.

  • Examples of substances used internationally include poly-L-lactic acid and polycaprolactone.

  • Effects: These substances work gradually, with changes reported over weeks to months.

  • Risks: Bruising, nodules, infection, and in rare cases vascular occlusion (blocked blood vessel).

  • Important: These procedures must only be performed by qualified prescribers due to the risk of serious complications.

Thread-Based Procedures

Absorbable threads (such as PDO or PLLA threads) are another method used in some settings. They provide temporary structural support and may stimulate collagen around the inserted material.

  • Duration: Effects are temporary and vary by thread type and placement.

  • Risks: Bruising, swelling, infection, asymmetry, or thread migration.

General Considerations

  • Results vary: Collagen stimulation is a biological process. Outcomes are not immediate and can differ widely.

  • Multiple sessions: Most techniques require repeated treatments over time.

  • Temporary effects: All results are time-limited and maintenance may be required.

  • Risks: All procedures carry the possibility of side effects, from mild (redness, swelling) to serious (infection, vascular injury, scarring, blindness in very rare cases).

  • Consultation required: Only a registered medical practitioner can determine suitability after reviewing medical history, expectations, and potential risks.

Summary

Collagen stimulation refers to a group of medical approaches aimed at influencing the body’s own collagen production. Options include microneedling, light-based devices, radiofrequency, injectables, and thread procedures.

Each carries potential risks as well as possible effects. None are permanent, and outcomes vary between individuals. Anyone considering these procedures should seek a consultation with a qualified health practitioner, where risks, benefits, and alternatives can be discussed in detail.

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